Differential Interaction of Virulent and Attenuated Infuenza Virus Strains with Ferret Alveolar Macrophages: Possible Role in Pathogenicity
Identifieur interne : 002093 ( Main/Exploration ); précédent : 002092; suivant : 002094Differential Interaction of Virulent and Attenuated Infuenza Virus Strains with Ferret Alveolar Macrophages: Possible Role in Pathogenicity
Auteurs : Bruce L. Riser ; Hunein F. Maassab [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Effet cytopathogène viral, Furets, Influenzavirus C (physiologie), Liquide de lavage bronchoalvéolaire (cytologie), Macrophages (microbiologie), Orthomyxoviridae (pathogénicité), Orthomyxoviridae (physiologie), Réplication virale, Technique d'immunofluorescence, Virulence, Virus de la grippe A (physiologie), Virus influenza B (physiologie).
- MESH :
- cytologie : Liquide de lavage bronchoalvéolaire.
- microbiologie : Macrophages.
- pathogénicité : Orthomyxoviridae.
- physiologie : Influenzavirus C, Orthomyxoviridae, Virus de la grippe A, Virus influenza B.
- Animaux, Cellules cultivées, Effet cytopathogène viral, Furets, Réplication virale, Technique d'immunofluorescence, Virulence.
English descriptors
- KwdEn :
- Animals, Bronchoalveolar Lavage Fluid (cytology), Cells, Cultured, Cytopathogenic Effect, Viral, Ferrets, Fluorescent Antibody Technique, Influenza A virus (physiology), Influenza B virus (physiology), Influenzavirus C (physiology), Macrophages (microbiology), Orthomyxoviridae (pathogenicity), Orthomyxoviridae (physiology), Virulence, Virus Replication.
- MESH :
- cytology : Bronchoalveolar Lavage Fluid.
- microbiology : Macrophages.
- pathogenicity : Orthomyxoviridae.
- physiology : Influenza A virus, Influenza B virus, Influenzavirus C, Orthomyxoviridae.
- Animals, Cells, Cultured, Cytopathogenic Effect, Viral, Ferrets, Fluorescent Antibody Technique, Virulence, Virus Replication.
Abstract
The ferret provides a unique model for the study of human influenza. The interaction between alveolar macrophages and virus strains with different levels of virulence was examined in vitro. The greater virulence ofwild-type A strains over type Band C viruses was reflected in the higher production of infectious virus progeny and subsequent cytopathology, even though the expression of viral antigens wasequivalent for all strains tested. These included A/Ann Arbor/6/60 (H2N2) and A/Rochester/1/82 (H3N2), B/Hong Kong/72, and C/Ann Arbor/1/50. The attenuated coldadapted and temperature-sensitive variant of A/Ann Arbor/6/60 behaved like its parent except that a longer period was needed to reach peakviral release. In contrast, the avirulent host-range reassortant CR-43-3 did not productively replicate, though viral antigen expression was comparable to that of the other strains. Type C virus infected few cells and these continued to release low virus levels in the absence of detectable cytopathology. The results suggest that the ability of certain strains to infect and replicate in alveolar macrophages can be correlated to their in vivo virulence and may play a role in determining the course of viral pathogenesis.
Url:
DOI: 10.1093/infdis/161.4.699
Affiliations:
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Maassab, Dept. of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St., Ann Arbor</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1990-04">1990</date><biblScope unit="vol">161</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="699">699</biblScope><biblScope unit="page" to="705">705</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bronchoalveolar Lavage Fluid (cytology)</term><term>Cells, Cultured</term><term>Cytopathogenic Effect, Viral</term><term>Ferrets</term><term>Fluorescent Antibody Technique</term><term>Influenza A virus (physiology)</term><term>Influenza B virus (physiology)</term><term>Influenzavirus C (physiology)</term><term>Macrophages (microbiology)</term><term>Orthomyxoviridae (pathogenicity)</term><term>Orthomyxoviridae (physiology)</term><term>Virulence</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Effet cytopathogène viral</term><term>Furets</term><term>Influenzavirus C (physiologie)</term><term>Liquide de lavage bronchoalvéolaire (cytologie)</term><term>Macrophages (microbiologie)</term><term>Orthomyxoviridae (pathogénicité)</term><term>Orthomyxoviridae (physiologie)</term><term>Réplication virale</term><term>Technique d'immunofluorescence</term><term>Virulence</term><term>Virus de la grippe A (physiologie)</term><term>Virus influenza B (physiologie)</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Liquide de lavage bronchoalvéolaire</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bronchoalveolar Lavage Fluid</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Influenzavirus C</term><term>Orthomyxoviridae</term><term>Virus de la grippe A</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term><term>Influenzavirus C</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Cytopathogenic Effect, Viral</term><term>Ferrets</term><term>Fluorescent Antibody Technique</term><term>Virulence</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Effet cytopathogène viral</term><term>Furets</term><term>Réplication virale</term><term>Technique d'immunofluorescence</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">The ferret provides a unique model for the study of human influenza. The interaction between alveolar macrophages and virus strains with different levels of virulence was examined in vitro. The greater virulence ofwild-type A strains over type Band C viruses was reflected in the higher production of infectious virus progeny and subsequent cytopathology, even though the expression of viral antigens wasequivalent for all strains tested. These included A/Ann Arbor/6/60 (H2N2) and A/Rochester/1/82 (H3N2), B/Hong Kong/72, and C/Ann Arbor/1/50. The attenuated coldadapted and temperature-sensitive variant of A/Ann Arbor/6/60 behaved like its parent except that a longer period was needed to reach peakviral release. In contrast, the avirulent host-range reassortant CR-43-3 did not productively replicate, though viral antigen expression was comparable to that of the other strains. Type C virus infected few cells and these continued to release low virus levels in the absence of detectable cytopathology. The results suggest that the ability of certain strains to infect and replicate in alveolar macrophages can be correlated to their in vivo virulence and may play a role in determining the course of viral pathogenesis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><noCountry><name sortKey="Riser, Bruce L" sort="Riser, Bruce L" uniqKey="Riser B" first="Bruce L." last="Riser">Bruce L. Riser</name></noCountry><country name="États-Unis"><region name="Michigan"><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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